Plant Defense and Disease Resistance!

Plants are weird. Maybe I should be a bit more specific. Plants have weird immune systems.

Scientists know a lot about how the plant immune system works, but there is still a lot we don’t know! Researchers at Duke University have learned a bit more about the plant immune system, and what they’ve learned could help make a better disease-resistant plant which could lower pesticide use!

We’re going to conquer a lot of info right now because these researchers published their findings in not one, but two different papers published back to back in the same journal! The first paper was on a new aspect of the plant immune system and the second one took that new knowledge and applied it to the creation of a disease-resistant plant!

So why do we want disease-resistant plants? Obviously, we want our plants to be healthy and delicious, but disease-resistant plants could limit the use of pesticides. If plants are better able to defend themselves, then they won’t need the help of pesticides.

The problem is that disease-resistant plants are difficult to get. Plants have two states of being. Growth mode and defense mode. But they can only be in one of those states at a time. So you can have a plant that is really good at defending itself but is really shrimpy or you can have a big plant that is prone to infection.  What we really need are some cheat codes that will give us a really big plant that is good at defending itself. And these researchers may have found that cheat code.

In order to get how their discovery enables that cheat code, we need to understand how the plant immune system works. Compared to humans and other animals, plants have a really weird immune system. Humans have innate and adaptive immunity. Our innate immune system has general defense against pathogens and our adaptive immune system focuses on taking down individual pathogens like the flu or chicken pox. The adaptive immune system is what works when you get a vaccine.

Plants don’t have an adaptive immune system. They only have an innate one. And even their innate system is different. They don’t have immune cells.

Instead of having cells that just do immune work, all plant cells have immune capabilities. They all have proteins on their surface that recognize different molecules from a variety of pathogens. Once they recognize those molecules, they sound the alarm and start a cascade of events that puts the plant into defense mode.

The ultimate goal of defense mode is to get proteins that will help defend the plant against the invading pathogen, but there are a couple of ways to get more defensive proteins. To get a defensive protein, you have a defensive protein gene that gets copied and then that copy gets read into protein.   

If you want more protein you can either increase the number of copies you make or increase the speed or number of times that you read that copy. 

Because there are two controlling steps in this process, the number of copies you have doesn’t guarantee how much protein you’ll have. Just like the number of books you own, doesn’t mean you’re well read. You could own 50 books but only ever read one of them.

Scientists knew that when plants recognize that they have a pathogen, they change the number of defensive protein gene copies they have, but we were missing part of the story. These researchers looked specifically at how plant cells read these copies when switching from growth mode to defense mode.

They found out that the copies of defensive protein genes have a special signal on them that tells the cell to only read that copy when the pathogen is around. This may just seem like a fun quirk of the plant immune system, but this makes a huge difference in the agriculture business!

These researchers tried putting the special signal on copies of genes that provide a broad protective effect for the plant. Usually, this kind of broad protective protein takes up a lot of the plant’s energy and makes it small, but safe. By putting the special signal on it, you get a plant that is really quick to respond to infections without actually being in defense mode! 

It’s kind of like having a neighborhood watch instead of a full police force. The police force takes a lot of energy and resources, but the neighborhood watch can be just as effective at dealing with trouble without all the costly resources.

This work was done in a small flowering weed called Arabidopsis and also in rice, but future work will have to test whether the special signal works in other plants too.

Maybe this new understanding of plant immune systems can help keep our plants healthy, happy, and pesticide-free for the days to come. 

 

Information in the article comes from Xu et al. “Global translational reprogramming is a fundamental layer of immune regulation in plants” Nature (2017) and Xu et al. “uORF-mediated translation allows engineered plant disease resistance without fitness costs” Nature (2017).

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